TMPRSS2 and Pallister-Hall syndrome: Variant rs16901979 at 8q24 was found to be associated with TMPRSS2:ERG negative PrCa, in both the discovery and replication datasets in our study (OR = 0.53; P = 0.02 and OR = 0.53, P = 0.01, respectively; P = 0.0007 combined); however this was not the case in the PHS/HPFS cohorts (OR = 0.78; P = 0.48).