AKT1 and breast cancer: Mammary tumors from p53fl/fl;KrasG12D;myr-p110αwt/fl and p53fl/fl;KrasG12D;myr-p110αfl/fl had significantly increased levels of total p110α (1.3-fold) and p-AKT levels (1.3-fold), as compared with p53fl/fl;myr-p110αwt/fl and p53fl/fl;myr-p110αfl/fl mammary tumors as shown in Figures 3c and d.