p53fl/fl;KrasG12D;myr-p110αwt/fl mammary tumors with one copy of myr-p110α had further elevated expression levels of total p110α (39-fold), and this resulted in increased p-AKT levels by 48-fold and increased p-AKT/AKT ratio (52-fold; Figures 2c and d). The gene discussed is AKT1; the disease is breast cancer.