All three stepwise selection approaches revealed older age, male gender, and the number of catheters and drainages as predictors for delirium, independent of possible confounders (i.e., age, gender, SAPS II, SAS, SOFA scores, dementia and/or leukoencephalopathy, and albumin serum levels). The gene discussed is ALB; the disease is Leukoencephalopathy.