Interestingly, a recent large genome-wide association study of incident stroke conducted by the CHARGE consortium, followed by replication in studies with prevalent stroke (mostly from the NINDS-SiGN and METASTROKE consortia), identified common variants on chr6p25 near FOXF2 to be associated with all stroke, and this association was particularly strong with small artery occlusion ischemic stroke compared to other stroke subtypes [39•]. This evidence concerns the gene FOXF2 and stroke disorder.