At the other end of the spectrum, unaffected women whose mother or sister with high grade triple negative breast cancer is unavailable for testing and whose family history is strongly predictive of a BRCA1/2 mutation, (such as a BOADICEA likelihood in the relative of >80% or a pathology adjusted Manchester score of 30 or higher) should be reassured by a negative test. Here, BRCA1 is linked to triple-negative breast carcinoma.