AGT and Hypertension: In fact, previous results from our laboratory have shown that myofilament Ca2+ desensitization in LV myocytes from angiotensin II-induced hypertensive rat hearts was associated with greater [Ca2+]i [13] and myofilament Ca2+ desensitization with BDM increased [Ca2+]i in sham but not in hypertension (where myofilament Ca2+ sensitivity was reduced).