HMGB1 and acute kidney injury: Hence, the work presented here introduces a dual microarray platform for the multiplex and ultrasensitive detection of two biomarkers, the High Mobility Group Box 1 (HMGB-1) and Kidney Injury Molecule-1 (KIM-1) biomarkers, which have shown potential prognostic value in acute liver disease12, 13, 14 and acute renal failure respectively15.