There were no differences between aged APP/PS1dE9 mice compared with WT controls in the expression of Nr1d1 and Nr1d2 (Supplemental Fig. 3B), two additional E-box genes, possibly because these genes, which are representative of a secondary loop in the circadian network62, are not susceptible to the AD pathology. The gene discussed is NR1D2; the disease is Alzheimer disease.