This led to the identification of hyperphosphorylated kinases such as YES proto-oncogene 1, Src family tyrosine kinase (YES1), epidermal growth factor receptor (EGFR), LYN proto-oncogene (LYN), EPH receptor A2 (EPHA2) and DYRK1A in the HNSCC cell lines. Here, YES1 is linked to head and neck squamous cell carcinoma.