SLC2A1 and neoplasm: In this study, we have found that JB downregulated the mRNA expression of glucose transporter genes (Glut1, Glut3 and Glut4) and glycolysis-related kinase genes (Hk2 and Ldha), increased ROS level and decreased the potential of mitochondrial membrane, and subsequently induced tumor cells apoptosis in B16F10 cells.