The link between obesity and insulin resistance is disrupted by gene knockout of mediators of inflammatory pathways such as Toll-like Receptor (TLR)5, 6, 7, 8, TNF-family cytokine receptor (TNFR)9, and nucleotide-binding domain, leucine-rich repeats containing family, pyrin domain-containing-3 (Nlrp3) inflammasome10. This evidence concerns the gene TNFRSF1A and obesity due to melanocortin 4 receptor deficiency.