2010; Williams et al. 2014). However, this study highlights the importance of astrocyte–BBB interaction. Disruptions in astrocyte development may also dysregulate P‐gp at the developing BBB, which may contribute to the CNS dysfunction in neurodevelopmental disorders. Moreover, many conditions have been shown to alter the timing of astrocyte maturation. Prenatal chronic hypoxia and inflammation can delay the maturation of astrocytes in the fetal brain – an effect that has been shown to persist later in life (Tilleux and Hermans 2008; Raymond et al. 2011). Here, PGP is linked to neurodevelopmental disorder.