IGF1 and 3-M syndrome: However, in view of the genetic profile of the patient (leading us to 3M diagnosis) and previous studies suggesting a degree of GH resistance as well as GH deficiency being possibly related with the 3M syndrome, and previous studies reporting that the 3M syndrome may be associated with the dysregulations of GH, IGF1, and IGF binding proteins, we refrained from applying the clonidine stimulation test to our patient (5).