No simple explanation seems to explain the disparate findings of Yuan et al. [56] and Yue et al. [54] on whether myocardial CXCL10 is harmful or beneficial in the context of acute CVB3 myocarditis, although timing and dosage levels of CXCL10 and effective viral clearance versus Th1 recruitment are likely contributing factors. Here, CXCL10 is linked to myocarditis.