As a vehicle formicroRNA-145 delivery, PU-PEI mediates miR-145 overexpression and inhibits the properties of LAD-CSCs by repressing its downstream targets, Oct4, Sox2, and Fascin1 (Chiou et al. 2012), which provides a novel miRNA-based approach for the treatment of LAD by artificially enhanced expression of microRNA-145 (Fig. 2). Here, SOX2 is linked to leukocyte adhesion deficiency.