SOX2 and leukocyte adhesion deficiency: miRNA-145 was found to be expressed at low levels in lung adenocarcinoma (LAD)-associated CSCs and was further validated to inhibit the proliferation of LAD-CSCs and be negatively correlated with the levels of Oct4/Sox2/Fascin1 in LAD patient specimens (Chiou et al. 2012; Zhang et al. 2011; Hu et al. 2014).