In addition our study, mothers with gestational diabetes, hypertension, asthma, chronic disease, use of drug or a history of smoking exposure were not included, because Garces et al. recently reported that circulating irisin levels in pregnant women with preeclampsia were lower compared to women with healthy pregnancies in the third trimester (Garces et al. 2014). Here, FNDC5 is linked to preeclampsia.