More recently, T-cell immunoglobulin mucin 3 and T-cell immunoglobulin mucin 4 (TIM-3 and TIM-4) were described to be markers of histiocytic and dendritic neoplasms; however, due to their expression on dendritic cell neoplasms, Langerhans cell histiocytosis, and cases of acute monocytic leukemia, they might not be ideal to confirm HS [1]. This evidence concerns the gene TIMD4 and Langerhans cell histiocytosis.