Mediates the processes of lymphocyte activation, adhesion, migration (lymphocyte rolling and homing), embryonic development, angiogenesis, placental tissue remodeling in placentogenesis, as well as invasion and growth of tumor cells, inflammation. Stabilization of ECM and glycocalyx, biodegradation of HA, induction of CD4+CD25+ T-regulatory cells. This evidence concerns the gene CD4 and neoplasm.