An intraperitonealinfection of recombinant Pdx1 into streptozotocin-induced diabetic mice inducedamelioration of hyperglycemia [123].Ductal cells of adult mice transduced with an adenoviral vector carrying thePdx1, Pax4, Ngn3, and NeuroD genes start insulin secretion [124]. The gene discussed is INS; the disease is Hyperglycemia.