Cytokines and growth factors associated with tumor progression.The macrophage colony-stimulating factor (M-CSF) and IL-6 areimportant factors that are involved in the differentiation of monocytes [78, 79]and suppress the differentiation of DCs [80] by increasing the expression of M-CSF receptors inparallel with a reduction of the amount of GM-CSF α-receptors in pre- DCs.Similar phenomena are also characteristic of the IL-10 produced by tumor cells[81, 82]. This evidence concerns the gene IL10 and neoplasm.