An interesting study showed that miR-17-92 cluster is down-regulated in pancreatic cancer stem cells (CSCs), which showed highly resistant to chemotherapy by activating NODAL/ACTIVIN/TGF-β1 signaling pathways, thus, suppression of these pathways may enhance the sensitivity of pancreatic CSCs to chemotherapy [11]. The gene discussed is TGFB1; the disease is familial pancreatic carcinoma.