TGFB1 and familial pancreatic carcinoma: miRNAs such as miR-21, miR-143, miR-155, miR-130a/301a/454, miR-224, miR-146a, miR-483-3p, miR-494, miR-494, and miR-421 are involved in pancreatic cancer progression by regulating TGF-β/SMAD-4 signaling either directly or indirectly [3].