TNC and acute myeloid leukemia: These DMR were located within the genes TNXB and HOXA4, which are notable because TNXB is a member of the tenascin family and regulates cell-extracellular matrix interactions [42, 43] and HOXA4 is a transcription factor previously shown to inhibit cell motility and to be aberrantly methylated in acute myeloid leukemia [44, 45] (Fig. 6).