NTRK2 and Barrett esophagus: The effect of DNA methylation on NTRK2 in BE and HGD/EAC is not clear at this time as its expression in BE or HGD is similar to normal esophagus based on publically available gene expression data, whereas NTRK3 is normally overexpressed in EAC (but not BE) vs. normal esophagus (expression level 1.03–1.79; www.oncomine.org).