CLDN11 and cancer: Among the HGD/EAC cases, we identified 29 DMR, including areas with altered methylation in the genes GFI1, which is a transcriptional repressor implicated in the regulation of p53 activity and Notch signaling [46, 47] and CLDN11, a cell adhesion protein involved in cell migration that is commonly altered in cancer [48] (Fig. 6).