INS and metabolic syndrome: It is also interesting, but not surprising, that the gene expression patterns with regards to insulin signalling observed in the present study were not found in previous hepatic transcriptomic analyses of BALB/c mice tested on a low-fat diet [65] (with the exception of up-regulated cytochrome P450 genes), given a high-fat atherogenic diet [67] or injected with myeloma cells [66], as mice are not predisposed to T2DM since they are HDL animals in general and do not easily develop the metabolic syndrome.