LEP and obesity due to melanocortin 4 receptor deficiency: Four studies reported similar levels of IL-6 [6, 17, 19, 24] and five studies reported similar levels of adiponectin [6, 16, 17, 19, 24] between obese and nonobese individuals with CP, whereas 3 studies reported comparable levels of GCF leptin among CP patients with and without obesity [6, 19, 24].