As shown in Fig. 5g, the concentrations of IL-6, IL-1β, and TNF-α in sera of mice with endotoxemia treated with N4 (758.02, 147.69, and 143.78 pg/ml, respectively) or PMB (514.91, 242.82, and 74.03 pg/ml, respectively) were significantly lower than those of the LPS control group (1026.76, 292.87, and 394.89 pg/ml, respectively). This evidence concerns the gene IL6 and serum lipopolysaccharide activity.