TNF and infection: As for serum cytokines (Figure 4i), cytokine production by macrophages from infected HFD mice at both 1 and 8 weeks post‐infection was significantly less pro‐inflammatory than cytokine production by macrophages from infected ND mice (Figure 6f–g), due to reduced TNF‐α production, but not increased IL‐10 secretion (Figure 6d–e).