TLR4 and Hyperglycemia: TLR4 is not required for immune responses to B. burgdorferi infection in vivo, but contributes to B. burgdorferi‐elicited cytokine secretion in macrophages, promotes the development of insulin‐resistant hyperglycemia in response to HFD, and is a key metabolic sensor of lipids (Glickstein & Coburn, 2006; Weis & Bockenstedt, 2010; Jin et al.