We observed a better preservation of auditory threshold and OHC survival in CDDP and PFT‐α‐treated TP53‐mutant HBCx‐14 tumor‐bearing mice (mean threshold: 48.4 dB SPL ± 5.5, and 80.1% ± 4.8 OHC survival at the frequency of 25 kHz), when compared with CDDP alone (mean threshold: 77.7 dB SPL ± 4.3, and 20.8% ± 4.5 OHC survival at the frequency of 25 kHz, Fig 6E–G). The gene discussed is TP53; the disease is neoplasm.