Despite over half of all human cancers lacking functional p53 (Soussi & Wiman, 2007), the presence of p53 within cancer stromal cells (endothelial cells or fibroblasts) may play an important role in tumor growth and tumor response to cytotoxic anticancer agents (Bar et al, 2010; Shtraizent et al, 2016). This evidence concerns the gene TP53 and neoplasm.