The variability in response to PEX may be linked to differences in PEX timing; MOG-IgG titers; intensity, extension, and site (e.g., ON vs. myelitis as seen in AQP4-IgG-positive NMOSD [35]) of inflammation; and, importantly, the number of PEX courses applied, which varied between 3 and 11 in the present cohort. Here, MOG is linked to myelitis.