Several clinical and radiological features hitherto thought to be typical for AQP4-IgG-positive NMO, such as longitudinally extensive spinal cord lesions, lesion location in the central portion of the spinal cord, longitudinally extensive optic nerve lesions, lesions involving the optic chiasm, area postrema lesions, intractable nausea and vomiting, and thalamic lesions, or for MS, such as INO or periventricular, subcortical, juxtacortical, and callosal white matter lesions, were present in some of our MOG-IgG-positive patients. This evidence concerns the gene AQP4 and neuromyelitis optica.