MACC1 and metastatic malignant neoplasm in the lymph nodes: There were also significant differences between the expression of MACC1 and tumor grade (P = 0.009), size of tumor (P = 0.009), invasion of depth (P < 0.001), lymph node metastasis (LNM) (P < 0.001), and tumor-node-metastasis (TNM) (P < 0.001).