This mutation mediates gain-of-function of EZH2 enzymatic activity leading to increased levels of trimethylated H3K27 (H3K27me3) [43] and resulting in down-regulation of Polycomb target genes such as TCF4, FOXP1, TCL1A, BIK, and RASSF6P in follicular lymphomas [44]. Here, EZH2 is linked to follicular lymphoma.