EZH2 and lung carcinoma: It is believed that EZH2 as part of the PRC2 suppresses cell specific transcriptional programs that mediate differentiation or apoptosis such as GSK-3β and p53 in cervical cancer [73], insulin-growth factor in lung cancer [74] p21 in ovarian cancer [75] and IKKα in nasopharyngeal carcinoma [76].