DNMT1 and neoplasm: In a recent study, Peng et al, using a mouse model of ovarian cancer, showed that epigenetic alterations of cancer cells by inhibition of EZH2 and DNA methyltransferase 1 (DNMT1) resulted in increased expression of the Th1-type chemokines CXCL9 and CXCL10 in cancer cells, leading to increased trafficking of effector T cells to the tumor site and decreased tumor volume [91].