EZH2 and cancer: This study also determined that different KRAS mutations can promote the expression of EZH2 through PI3K-AKT or MEK-ERK signaling in non-small cell lung cancer, a finding that allows for therapeutic combinations of pathway targeting agents, such as AKT and EZH2 inhibitors or MEK and EZH2 inhibitors, to achieve maximum therapeutic benefit in cancers which display joint aberration of these targets [52].