EZH2 and neoplasm: Ezh2-null hematopoietic stem and progenitor cells (HSPCs) or HSPCs treated with Ezh2 inhibitors gave rise to increased NK precursors and mature progeny that display enhanced cytotoxicity against tumor cells and these functional outcomes were associated with up-regulation of IL-15R (CD122) and the NKG2D-activating receptor [93].