EZH2 and Familial prostate cancer: It should be noted though that EZH2 activity has also been associated with transcriptional activation of oncogenic signaling pathways associated with CSC survival and proliferation such as Wnt signaling in colorectal cancer [73, 77], NOTCH1 and TGFβ1 in prostate cancer [78], and STAT3 pathway in glioblastoma [65].