EZH2 and metastatic malignant neoplasm in the lymph nodes: EZH2 expression in colorectal cancer was reported to positively associate with TNM stage and lymph node metastasis [21] while another study evaluating the role of EZH2 expression in gastrointestinal malignancies, found that its overexpression is correlated with poor prognosis in esophageal but not colorectal and gastric cancer [22].