Using the generated mouse strain, we will obtain further insight into the involvement of Ndst4 in intestinal diseases through dextran sulfate sodium-induced colitis and azoxymethane/dextran sulfate sodium-induced tumorigenesis models, which are particularly useful tools for elucidating the tumor suppressor roles of NDST4 in the tumorigenesis and progression of human colorectal cancer. This evidence concerns the gene NDST4 and intestinal disorder.