Other signaling pathways related to endocytosis, Wnt, ECM-receptor, neurotropin, Glutamatergic, insulin, protein digestion/absorption, ErbB, Gap junction, mTOR, melanoma, phosphatidylinositol, adherens junction, GnRH, Fc epsilon RI, and circadian rhythm are also significantly affected (p<0.001). This evidence concerns the gene INS and melanoma.