The apparent overexpression of MET at mRNA and protein levels, using qRT-PCR, microarray transcriptional profiling and IHC, has been reported by a number of independent groups in CRC [24, 26, 45–48], with a recent meta-analysis of a number of these studies offering the consensus that overexpression of c-MET and HGF occurs at a frequency of up to ~78% and ~95% respectively [49]. This evidence concerns the gene HGF and colorectal carcinoma.