Further data showed significant increases in HGF mRNA and protein levels in CCD-18Co cells compared to levels measured in the HCT116 cells (Supplementary Figures S1 and S3C), indicating that myofibroblast-derived HGF plays a key role in c-MET activation and migration/invasion of CRC cells following co-culture with CCD-18Co cells. This evidence concerns the gene HGF and colorectal carcinoma.