ETV5 and melanoma: In agreement with our previous results obtained in RPM-MC cells, depletion of either CPI-17 or ERM expression (Figure 4A) in M21 melanoma cells led to a significant decrease in proliferation (Figure 4B), Ras activation (Figure 4C), and strongly inhibited cellular transformation (Figure 4D, Supplementary Figure S3); further demonstrating CPI-17's tumorigenic potential involving ERM proteins in melanoma cells.