Depletion of CPI-17 in RPM-MC cells lowered ERM phosphorylation (Figure 3A), while depletion of ERM proteins alleviated CPI-17's effect on Ras activation (Figure 3B) and soft agar colony formation (Figure 3C); confirming ERM proteins as important components of CPI-17's oncogenic role in melanoma cells. The gene discussed is ETV5; the disease is melanoma.