A previous study reported that SIRT1 mRNA and protein are overexpressed in pancreatic cancer tissues, and increased SIRT1 expression was correlated with tumours from patients > 60 years of age, or with tumours > 4 cm, a higher TNM stage or the presence of lymph node or hepatic metastases [36]. The gene discussed is SIRT1; the disease is familial pancreatic carcinoma.