Two of the other adaptor proteins are extracellular signal-regulated kinase mitogen-activated protein kinase (ERK1/2-MAPK) and activator protein (AP)-1, related to DDR-2-mediated induction of the promoter activity of matrix metalloproteinase-13, which is involved in articular cartilage destruction in rheumatoid arthritis [30]. This evidence concerns the gene DDR2 and rheumatoid arthritis.