DDR2 and neoplasm: These include upregulation of DDR2 and ROR2 and down-regulation of ERBB3. Among them, DDR2 is the most significantly upregulated that showed log2 ratios of 0.9193-fold and 0.8109-fold upregulation related to the increment of primary tumor (pT) status and presence of metastasis (both P < 0.0001, Table 1).