DDR1 and DDR2 bind to a specific amino acid motif (GVMGFO) in fibrillar collagen I-III and V. The different preferences arouse the hypothesis that cancer cells may hijack different DDRs to invade different extracellular circumstances and that they may serve as one of the cancer hallmarks: activating invasion and metastasis [25, 26]. Here, DDR2 is linked to cancer.