Overall, the top 7 overexpressed (>16-fold) genes in GIST relative to ICC (in descending order) are HIPK2 (homeodomain-interacting protein kinase 2), IFT52, FOXF1 (forkhead box F1), RB1 (retinoblastoma 1), PtTCH1, RAB23, and TGFBR2 (transforming growth factor beta receptor II). This evidence concerns the gene RB1 and intrahepatic cholangiocarcinoma.