Given the reported presence of primary cilia (PC) in GIST [25, 26], as well as the importance of PC in Hedgehog signaling transduction, it is also noteworthy that four proteins responsible for anterograde trafficking of cargo in PC, namely, KIF3A (encoding kinesin family member 3A), IFT52 (intraflagellar transport 52), IFT88 (intraflagellar transport 88), and IFT172 (intraflagellar transport 172), were significantly overexpressed in GIST as compared to ICC (Figure 3B). Here, IFT172 is linked to intrahepatic cholangiocarcinoma.