Overall, the top 7 overexpressed (>16-fold) genes in GIST relative to ICC (in descending order) are HIPK2 (homeodomain-interacting protein kinase 2), IFT52, FOXF1 (forkhead box F1), RB1 (retinoblastoma 1), PtTCH1, RAB23, and TGFBR2 (transforming growth factor beta receptor II). The gene discussed is TGFBR2; the disease is intrahepatic cholangiocarcinoma.