RHO and gastrointestinal stromal tumor: The Wnt and Notch pathways are important in GIST biology [40, 41], and collagen triple helix repeat containing 1 (CTHRC1), an activator of Wnt/planar cell polarity-Rho signaling, was shown to induce GIST migration and invasion, as well as correlated with recurrence risk score, disease-free survival and overall survival in 412 GIST patients [40].