However, only a small amount evidence has been accumulated to indicate a role for the Hedgehog pathway in GIST.[17] SHH, PTCH1, SMO, and GLI1 expression were detected by immunohistochemistry in one study [18], and chromosome 7p amplification was found to be associated with increased GLI3 expression [19]. Here, GLI1 is linked to gastrointestinal stromal tumor.