SIX is enriched in the CD44+CD24-/low subpopulation [140], whereas DACH might act as a tumor suppressor to reduce the number of BCSC subpopulations in vitro and in vivo though phosphorylating GSK3β and inhibiting Wnt signaling, compliance with findings in colorectal carcinomas [141, 142]. Here, GSK3B is linked to colorectal carcinoma.