Treatment with resveratrol, which inhibited the endogenous FoxO1 activity, led to an increase of type I fiber related gene troponin (slow) and myoglobin [79] and prevented TNF-α-induced muscle atrophy [96], whereas constitutively active FoxO1 mutant significantly blocked the resveratrol-induced increased expression of these two genes. The gene discussed is FOXO1; the disease is Atrophy.