However, the contribution of macrophage AEG-1 to tumor progression was associated with many other cytokines and growth factors, more researches are required to be done to investigate the underlying mechanism that how AEG-1 in macrophages exerts its full effect on the production of IL-6 and other cytokines as well as growth factors closely involved in tumor cell invasion and metastasis. This evidence concerns the gene MTDH and neoplasm.