Strong evidence shows that AEG-1 markedly increased interaction with the p65 subunit of NF-κB that induced the expression of NF-κB downstream genes in HeLa cells [18] and inhibition of NF-κB activation in macrophages abrogated initiation and progression of HCC in AEG-1 knockout mice [14]. Here, NFKB1 is linked to hepatocellular carcinoma.