Therefore, to understand the signaling mechanism mediated by HS-173, a PI3K inhibitor on EMT process, we first identified the expression of Vimentin and Ecadherin, representative EMT markers and then observed the changes of p-AKT and p-mTOR, which are downstreams of the PI3K/AKT signaling pathway in TGF-β-induced pancreatic cancer cells. This evidence concerns the gene CDH1 and familial pancreatic carcinoma.