However, as illustrated in Figure 3, analysis of TCGA breast cancer RNAseq data in primary tumor (n = 765), adjacent normal (n = 93) and metastasis (n = 6) showed that HELQ, FAM175A and HPSE, but not MRPS18C, were all found to be differentially expressed between normal breast and tumor tissue (P = 1x10-45, P = 6.6x10-31, P = 7.3x10-10, and P = 0.28, respectively, as determined by a Kruskal-Wallis rank sum test). The gene discussed is HPSE; the disease is breast cancer.