All variants associated with overall breast cancer risk with P < 10-2 included in Table 1 were also evaluated for association with breast cancer risk in BRCA1 and BRCA2 mutation carriers within the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA) in a total of 15 252 BRCA1 and 8 211 BRCA2 carriers. The gene discussed is BRCA1; the disease is breast cancer.