HELQ and breast cancer: In the breast cancer tissue dataset BC241, the most strongly expression-associated SNP at this locus was our top risk SNP rs11099601, which was associated with expression levels of HELQ, (with P = 8.28x10-14 and r2 = 0.20, where the r2 value indicates the percentage of variance in HELQ expression levels explained by rs11099601) (Figure 6A).