Further analysis comparing the tumor expression levels of these genes between the 5 molecular subtypes of breast cancer, namely: Luminal A, Luminal B, Her2-enriched, Basal-like and Normal-like, showed that while HELQ and FAM175A expression levels are decreased in Basal-like tumors (P = 1.3x10-18 and P = 3.5x10-36, respectively (Kruskal-Wallis test), MRPS18C and HPSE expression were found to be up regulated in Basal-like carcinomas (P = 1.2x10-5, P = 1.6x10-33) (Figure 4). This evidence concerns the gene HPSE and breast cancer.