HELQ and head and neck cancer: Moreover, a GWAS of upper aero-digestive tract cancers conducted by the International Head and Neck Cancer Epidemiology Consortium identified rs1494961, a missense mutation V306I in the second exon of HELQ gene perfectly correlated with rs11099601 (r2 = 1), to be associated with increased risk of upper aero-digestive tract cancers in their combined analysis (P = 1x10-8) [55].