The genetic implication of PHACTR1 in FMD, the subtle impairment in the development of vasculature in zebrafish, in addition to the evidence from recent GWAS describing an increasing number of loci with genes involved in vessel wall biology in CAD and MI[28] all support PHACTR1 plays a key etiological role in vascular structure. This evidence concerns the gene PHACTR1 and coronary artery disorder.