PHACTR1 is a confirmed susceptibility locus for coronary artery disease (CAD) and myocardial infarction (MI),[15,16] migraine[17,18] and more recently cervical artery dissection (CeAD), a rare condition defined as a mural hematoma in a carotid or vertebral artery and a cause of stroke.[19] Of note, the association of rs9349379 is in the opposite direction for FMD, CeAD and migraine, with rs9349379-A at risk, when compared to CAD and MI with rs9349379[G] allele at risk. This evidence concerns the gene PHACTR1 and coronary artery disorder.