To define whether and to which extent any of these sensing pathways control systemic type I IFN secretion during severe malaria in vivo, we first inoculated Myd88-/-, StingGt/Gt or control WT mice with Py YM, and measured blood and bone marrow IFNα/β levels at its peak (d 1.5) of production (Fig 4A and S4A Fig). Here, IFNA1 is linked to malaria.