Among the two postlingual SNHL families (SH151 and SB116) carrying p.P240L, the trans allele of p.P240L of CDH23 from SH151-324 was p.R1588W; however, none of the potential polymorphisms of CDH23 in trans with p.P240L was compatible with the segregation of SNHL in SB116. This evidence concerns the gene CDH23 and sensorineural hearing loss disorder.