In brief, we estimated the carrier frequency of CDH23 mutations in postlingual adult-onset inherited hearing loss, which were segregated in either a sporadic or autosomal recessive (AR) fashion based on the ethnic-specific minor allele frequency (MAF) filtering process to investigate the contribution of CDH23 and further tried to delineate the genotypic hierarchy of CDH23 mutations that determine the fate of DFNB12. Here, CDH23 is linked to hearing loss disorder.