Therefore, the allele frequency of these CDH23 variants associated with postlingual adult-onset SNHL was calculated to be 0.098% (95% CI, 0%–0.23%)(2/2040) among the 1020 ethnicity-matched control subjects from SGI, which was significantly lower than that of our adult study cohort (p<0.0001 by Chi-square test) (S1 Fig). The gene discussed is CDH23; the disease is sensorineural hearing loss disorder.