AGT and renal fibrosis: SHRs do not show a difference when compared with WKY rats regarding serum BUN or creatinine levels.39 However, renal fibrosis is increased in SHRs compared with WKY rats.40 Although the mechanisms leading to renal fibrosis are complicated, local factors, such as angiotensin II and transforming growth factor‐β, have been demonstrated to be involved in the pathogenesis of renal fibrosis.