EGFR and neoplasm: Mechanistically, CUR induces apoptosis in neoplastic cells by inhibiting numerous signaling pathways involved in tumor cell proliferation, such as AP-1, and STAT pathways, as well as a group of key kinases including protein kinase C, serine/threonine kinase (AKT), epidermal growth factor receptor (EGFR), extracellular signal-regulated kinase (ERK), and mitogen-activated protein (MAP) kinase in various cancer types [2].