SLC25A3 and obesity due to melanocortin 4 receptor deficiency: In this study, both 0.1% Res and Pic decreased body weight, perigonadal fat weight, and adipocyte size, but 0.25% Pic showed better anti-obesity ability than 0.1% Res and Pic in HFD-induced obese animal model, which was perhaps due to the difference of absorption between Res and Pic.