Four CIS were identified in multiple independent liver tumors harboring the hepatocellular carcinoma driver genes Fign, Braf, Sos1, and Dlk1-Dio3. Reverse-transcriptase PCR (RT-PCR) was performed and retroviral derived fusion transcripts were identified with the truncated proteins products having increased cellular activities. The gene discussed is BRAF; the disease is hepatocellular carcinoma.