The gene encoding CETP is shipped with 2056 polymorphic loci (https://www.ncbi.nlm.nih.gov/gene/1071), and some of them have been proposed as potential regulators of CETP deficiency and HDL cholesterol (HDL-C) increase, as indicated by a comprehensive meta-analysis of 92 published studies [4]. This evidence concerns the gene CETP and hyperinsulinemic hypoglycemia, familial, 4.