Lately, a large comprehensive meta-analysis choosing CETP gene TaqIB (rs708272) polymorphism as an instrument has demonstrated that circulating CETP may play a causal role in the pathophysiology of CHD [25], although there are still some unresolved issues revolving around the prerequisites of Mendelian randomization analysis [26], such as pleiotropic impact of genetic polymorphism under study and linkage disequilibrium with another locus that differently modifies circulating CETP. This evidence concerns the gene CETP and coronary artery disorder.